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Synthesis of some CC chemokines and their receptors in the synovium in rheumatoid arthritis.

Authors: Zhebrun, DA  Totolyan, AA  Maslyanskii, AL  Titov, AG  Patrukhin, AP  Kostareva, AA  Gol'tseva, IS 
Citation: Zhebrun DA, etal., Bull Exp Biol Med. 2014 Dec;158(2):192-6. doi: 10.1007/s10517-014-2720-9. Epub 2014 Nov 29.
Pubmed: (View Article at PubMed) PMID:25430645
DOI: Full-text: DOI:10.1007/s10517-014-2720-9

We studied the expression of some CC chemokines and their receptors in the synovium of patients with rheumatoid arthritis, osteoarthrosis, and a history of joint injury. In patients with rheumatoid arthritis, the levels mRNA for some angiogenic and proinflammatory chemokines (CCL5/RANTES, CCL11/eotaxin, CCL24/eotaxin-2, and CCL26/eotaxin-3) and their receptors (CCR1, CCR2, CCR3, CCR4, and CCR5) was elevated. mRNA expression correlated with activity, stage, and serological status of rheumatoid arthritis. Obtained data confirm the importance of CC chemokines as mediators of angiogenesis and inflammation in the synovium in rheumatoid arthritis.


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CRRD Object Information
CRRD ID: 10054499
Created: 2015-08-10
Species: All species
Last Modified: 2015-08-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.