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Crystallization of a soluble form of the rat T-cell surface glycoprotein CD4 complexed with Fab from the W3/25 monoclonal antibody.

Authors: Davis, SJ  Brady, RL  Barclay, AN  Harlos, K  Dodson, GG  Williams, AF 
Citation: Davis SJ, etal., J Mol Biol. 1990 May 5;213(1):7-10.
Pubmed: (View Article at PubMed) PMID:2338715
DOI: Full-text: DOI:10.1016/S0022-2836(05)80116-0

The structure of the T-lymphocyte cell surface glycoprotein CD4 is of considerable biological and medical interest. Recombinant rat CD4 expressed in soluble form in mammalian cells and complexed with W3/25 monoclonal Fab fragments formed crystals that diffract to 3.5 A and have the orthorhombic space group P2(1)2(1)2 or P2(1)2(1)2(1). The unit cell has dimensions a = 317 A, b = 161 A and c = 41.8 A and the asymmetric unit consists of two CD4:Fab complexes. These crystals are of suitable quality for X-ray diffraction analysis.


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CRRD Object Information
CRRD ID: 10058950
Created: 2015-08-11
Species: All species
Last Modified: 2015-08-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.