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Modulation of c-myc gene expression by extracellular stimuli in rat hepatoma cells.

Authors: Morimura, S  Kato, K  Tashiro, F  Ueno, Y 
Citation: Morimura S, etal., Jpn J Exp Med. 1990 Apr;60(2):51-6.
Pubmed: (View Article at PubMed) PMID:2200903

Modulation of c-myc gene expression by extracellular stimuli in H4IIE rat hepatoma cells was investigated by Northern blot analysis. Treatment of these cells with phorbol 12-O-tetradecanoate 13-acetate (TPA), insulin and concanavalin A (Con A) resulted in transient accumulation of c-myc transcripts within 2 hours. The induction of c-myc mRNA was dose dependent with similar responses for all three agents. The maximally induced c-myc mRNA levels varied from 5- to 15-fold of the control. Treatment with cycloheximide (10 micrograms/ml) and H7, a protein kinase C inhibitor (20 microM), inhibited this induction, suggesting that c-myc induction by these agents requires protein synthesis and protein kinase C activation.


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CRRD Object Information
CRRD ID: 10059628
Created: 2015-08-20
Species: All species
Last Modified: 2015-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.