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Cornichons control ER export of AMPA receptors to regulate synaptic excitability.

Authors: Brockie, PJ  Jensen, M  Mellem, JE  Jensen, E  Yamasaki, T  Wang, R  Maxfield, D  Thacker, C  Hoerndli, F  Dunn, PJ  Tomita, S  Madsen, DM  Maricq, AV 
Citation: Brockie PJ, etal., Neuron. 2013 Oct 2;80(1):129-42. doi: 10.1016/j.neuron.2013.07.028. Epub 2013 Oct 2.
Pubmed: (View Article at PubMed) PMID:24094107
DOI: Full-text: DOI:10.1016/j.neuron.2013.07.028

The strength of synaptic communication at central synapses depends on the number of ionotropic glutamate receptors, particularly the class gated by the agonist AMPA (AMPARs). Cornichon proteins, evolutionarily conserved endoplasmic reticulum cargo adaptors, modify the properties of vertebrate AMPARs when coexpressed in heterologous cells. However, the contribution of cornichons to behavior and in vivo nervous system function has yet to be determined. Here, we take a genetic approach to these questions by studying CNI-1--the sole cornichon homolog in C. elegans. cni-1 mutants hyperreverse, a phenotype associated with increased glutamatergic synaptic transmission. Consistent with this behavior, we find larger glutamate-gated currents in cni-1 mutants with a corresponding increase in AMPAR number. Furthermore, we observe opposite phenotypes in transgenic worms that overexpress CNI-1 or vertebrate homologs. In reconstitution studies, we provide support for an evolutionarily conserved role for cornichons in regulating the export of vertebrate and invertebrate AMPARs.


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CRRD Object Information
CRRD ID: 10400859
Created: 2015-09-19
Species: All species
Last Modified: 2015-09-19
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.