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Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes.

Authors: Iizuka, K  Takeda, J  Horikawa, Y 
Citation: Iizuka K, etal., FEBS Lett. 2009 Sep 3;583(17):2882-6. doi: 10.1016/j.febslet.2009.07.053. Epub 2009 Aug 4.
Pubmed: (View Article at PubMed) PMID:19660458
DOI: Full-text: DOI:10.1016/j.febslet.2009.07.053

Fibroblast growth factor 21 (FGF21) has beneficial effects of improving the plasma glucose and lipid profiles in diabetic rodents. Here, we investigated carbohydrate response element binding protein (ChREBP) involvement in the regulation of FGF21 mRNA expression in liver. Glucose stimulation and adenoviral overexpression of dominant active ChREBP increased FGF21 mRNA. Consistently, adenoviral expression of dominant negative Mlx inhibited glucose induction of FGF21 mRNA. Furthermore, deletion studies of mouse FGF21 gene promoter (-2000 to +65 bp) revealed a glucose responsive region between -74 and -52 bp. These findings suggest that FGF21 expression is regulated by ChREBP.


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CRRD Object Information
CRRD ID: 10401884
Created: 2015-10-09
Species: All species
Last Modified: 2015-10-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.