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Dietary linoleic acid and glucose enhances azoxymethane-induced colon cancer and metastases via the expression of high-mobility group box 1.

Authors: Ohmori, H  Luo, Y  Fujii, K  Sasahira, T  Shimomoto, T  Denda, A  Kuniyasu, H 
Citation: Ohmori H, etal., Pathobiology. 2010;77(4):210-7. doi: 10.1159/000296305. Epub 2010 Jul 7.
Pubmed: (View Article at PubMed) PMID:20616616
DOI: Full-text: DOI:10.1159/000296305

OBJECTIVE: High-mobility group box 1 (HMGB1) was closely associated with progression and metastasis of colorectal cancer. METHODS: We examined the significance of HMGB1 in causing colon carcinogenesis induced by azoxymethane (AOM) injection in Fischer 344 rats fed on a control diet (group C), a 15% linoleic acid (LA) diet (group L), a control diet with 10% glucose drink (group G), and a 15% LA diet with a 10% glucose drink (group L+G). RESULTS: Group L+G showed the highest body weight and calorie intake. Serum and mucosal HMGB1 levels were temporally increased in all groups, while the highest levels were observed in group L+G. Mucosal HMGB1 levels were correlated with cancer multiplicity and nodal metastases. In the AOM-injected rats fed the 15% LA diet with 10% glucose drink, administration of HMGB1 antibody suppressed serum HMGB1 concentration and cancer multiplicity. CONCLUSION: These data suggest that dietary LA and glucose provided the synergistic effect on AOM-induced rat colon cancer through HMGB1 induction.

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CRRD Object Information
CRRD ID: 10402080
Created: 2015-10-15
Species: All species
Last Modified: 2015-10-15
Status: ACTIVE



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