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Cytoplasmic dynein.

Authors: Allan, Victoria J 
Citation: Allan VJ, Biochem Soc Trans. 2011 Oct;39(5):1169-78. doi: 10.1042/BST0391169.
Pubmed: (View Article at PubMed) PMID:21936784
DOI: Full-text: DOI:10.1042/BST0391169

The organization and function of eukaryotic cells rely on the action of many different molecular motor proteins. Cytoplasmic dynein drives the movement of a wide range of cargoes towards the minus ends of microtubules, and these events are needed, not just at the single-cell level, but are vital for correct development. In the present paper, I review recent progress on understanding dynein's mechanochemistry, how it is regulated and how it binds to such a plethora of cargoes. The importance of a number of accessory factors in these processes is discussed.

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CRRD Object Information
CRRD ID: 10402142
Created: 2015-10-16
Species: All species
Last Modified: 2017-01-03
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.