Voltage-gated potassium currents within the dorsal vagal nucleus: inhibition by BDS toxin.

Authors: Dallas, ML  Morris, NP  Lewis, DI  Deuchars, SA  Deuchars, J 
Citation: Dallas ML, etal., Brain Res. 2008 Jan 16;1189:51-7. Epub 2007 Nov 9.
Pubmed: (View Article at PubMed) PMID:18048010
DOI: Full-text: DOI:10.1016/j.brainres.2007.10.090

Voltage-gated potassium (Kv) channels are essential components of neuronal excitability. The Kv3.4 channel protein is widely distributed throughout the central nervous system (CNS), where it can form heteromeric or homomeric Kv3 channels. Electrophysiological studies reported here highlight a functional role for this channel protein within neurons of the dorsal vagal nucleus (DVN). Current clamp experiments revealed that blood depressing substance (BDS) and intracellular dialysis of an anti-Kv3.4 antibody prolonged the action potential duration. In addition, a BDS sensitive, voltage-dependent, slowly inactivating outward current was observed in voltage clamp recordings from DVN neurons. Electrical stimulation of the solitary tract evoked EPSPs and IPSPs in DVN neurons and BDS increased the average amplitude and decreased the paired pulse ratio, consistent with a presynaptic site of action. This presynaptic modulation was action potential dependent as revealed by ongoing synaptic activity. Given the role of the Kv3 proteins in shaping neuronal excitability, these data highlight a role for homomeric Kv3.4 channels in spike timing and neurotransmitter release in low frequency firing neurons of the DVN.

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CRRD ID: 10412022
Created: 2015-11-11
Species: All species
Last Modified: 2015-11-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.