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Parkin and synphilin-1 isoform expression changes in Lewy body diseases.

Authors: Humbert, J  Beyer, K  Carrato, C  Mate, JL  Ferrer, I  Ariza, A 
Citation: Humbert J, etal., Neurobiol Dis. 2007 Jun;26(3):681-7. Epub 2007 Mar 27.
Pubmed: (View Article at PubMed) PMID:17467279
DOI: Full-text: DOI:10.1016/j.nbd.2007.03.007

Alternative splicing gives rise to at least seven parkin and eight synphilin-1 isoforms. Since both parkin and synphilin-1 have been involved in Lewy body (LB) formation, we decided to explore whether their isoforms are differentially expressed in LB diseases. With this aim, we studied relative mRNA expression levels of parkin and synphilin-1 isoforms in the frontal cortices of patients with dementia with LBs, the LB variant of Alzheimer's disease and Parkinson's disease and compared the findings with those obtained from Alzheimer's disease patients and control individuals. Duplex real-time PCR reactions, with beta-actin as internal standard, were carried out in a LightCycler. mRNA expression levels of parkin and synphilin-1 isoforms were seen to be specifically altered in each of the LB diseases studied. These findings suggest that parkin and synphilin-1 isoform expression changes play a significant role in the pathogenesis of LB diseases.

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CRRD Object Information
CRRD ID: 10412737
Created: 2015-11-24
Species: All species
Last Modified: 2015-11-24
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.