Interaction between poly(ADP-ribose) polymerase 1 and interleukin 1A genes is associated with Alzheimer's disease risk.

Authors: Infante, J  Llorca, J  Mateo, I  Rodriguez-Rodriguez, E  Sanchez-Quintana, C  Sanchez-Juan, P  Fernandez-Viadero, C  Pena, N  Berciano, J  Combarros, O 
Citation: Infante J, etal., Dement Geriatr Cogn Disord. 2007;23(4):215-8. Epub 2007 Feb 9.
Pubmed: (View Article at PubMed) PMID:17290104
DOI: Full-text: DOI:10.1159/000099471

Excessive release of proinflammatory cytokines by activated microglia surrounding senile plaques might contribute to the neurodegeneration associated with Alzheimer's disease (AD). Poly(ADP-ribose) polymerase 1 (PARP-1) is a nuclear protein recently implicated in the initial inflammatory response by modulating expression of inflammation-related genes, like interleukin 1 (IL-1). As PARP-1 overactivity has been shown in the AD brain, we tested the hypothesis that the PARP-1 -410 and -1672 polymorphisms would predispose people to AD due to overexpression of the PARP-1 gene, independently or in concert with the proinflammatory IL-1A -889 polymorphism. So, we performed a case-control study in 263 Spanish AD patients and 293 healthy controls. PARP-1 -410 and PARP-1 -1672 haplotypes were associated with an increased risk for AD (global haplotype association p value=0.019), and, in addition, PARP-1 haplotypes increased the risk of AD by interaction with the IL-1A -889 allele 2.

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CRRD ID: 10413885
Created: 2015-11-30
Species: All species
Last Modified: 2015-11-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.