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Systemic upregulation of PDGF-B in patients with neovascular AMD.

Authors: Zehetner, C  Kirchmair, R  Neururer, SB  Kralinger, MT  Bechrakis, NE  Kieselbach, GF 
Citation: Zehetner C, etal., Invest Ophthalmol Vis Sci. 2014 Jan 20;55(1):337-44. doi: 10.1167/iovs.13-12978.
Pubmed: (View Article at PubMed) PMID:24334449
DOI: Full-text: DOI:10.1167/iovs.13-12978

PURPOSE: To determine the plasma levels of platelet-derived growth factor-B (PDGF-B), VEGF, and TNF-alpha in patients with neovascular AMD and in patients with diabetic macular edema (DME). METHODS: Thirty patients with neovascular AMD, 30 patients with DME, and 12 healthy controls were included in this prospective study. The concentrations of PDGF-B, VEGF, and TNF-alpha were measured by ELISA. RESULTS: The PDGF-B concentration in the plasma of controls was (median [25th-75th percentile]) 263.5 (162.0-513.3) pg/mL and in patients with DME 219.0 (122.8-604.8) pg/mL. In patients with neovascular AMD, PDGF-B levels were significantly higher with a median plasma concentration of 783.5 (289.3-1183.5) pg/mL (P = 0.003). The VEGF concentrations in patients with DME 33.0 (21.8-73.0) pg/mL and in patients with neovascular AMD 55.0 (37.0-116.3) pg/mL showed no significant differences (P = 0.159). A positive correlation of PDGF-B and VEGF plasma levels was found in patients with neovascular AMD and in patients with DME (r = 0.683, P < 0.001, and r = 0.612, P < 0.001, respectively). No significant differences of systemic TNF-alpha levels could be found between the three study groups. CONCLUSIONS: Patients with neovascular AMD have significantly higher plasma PDGF-B levels compared with patients with DME and healthy controls. Our study data indicate that PDGF-B may be involved in the pathogenesis of neovascular AMD. (https://eudract.ema.europa.eu number, EudraCT 2010-024654-11)

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CRRD Object Information
CRRD ID: 10449444
Created: 2016-01-05
Species: All species
Last Modified: 2016-01-05
Status: ACTIVE



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