Elevated serum angiotensin converting enzyme levels as a reflection of bone marrow renin-angiotensin system activation in multiple myeloma.

Authors: Albayrak, M  Celebi, H  Albayrak, A  Sayilir, A  Yesil, Y  Balcik, OS  Yokus, O  Celik, T 
Citation: Albayrak M, etal., J Renin Angiotensin Aldosterone Syst. 2012 Jun;13(2):259-64. doi: 10.1177/1470320312437070. Epub 2012 Feb 16.
Pubmed: (View Article at PubMed) PMID:22345095
DOI: Full-text: DOI:10.1177/1470320312437070

INTRODUCTION: Angiotensin converting enzyme (ACE) is a circulating enzyme that participates in the body's renin-angiotensin system (RAS) and is localized on the endothelial cell surface in the lung and other vascular beds. It catalyses the conversion of decapeptide angiotensin I to octapeptide angiotensin II. In the present study, we aimed to analyse the possible relationship between the levels of ACE in the context of RAS in multiple myeloma (MM) pathogenesis. MATERIALS AND METHODS: The study was conducted on 25 MM patients (13 males, 12 females; median age 66 years, range 47-88) and 20 healthy controls. The clinical features of MM patients including demographics and laboratory findings were summarized. Serum ACE levels were measured by using commercially available kits. RESULTS: The serum ACE levels of MM patients and controls were 32.60+/-20.26 and 15.35+/-6.47 respectively. Serum ACE levels were significantly higher in MM patients compared with control groups (p<0.001). CONCLUSIONS: Being an important component of RAS, circulating ACE might be associated with clonal proliferation of malignant plasma cells in the bone marrow microenvironment. Identification of the pathobiological activity of the local RAS in MM would enlighten the biologic basis and clinical management of haematologic disorders.

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CRRD ID: 11038914
Created: 2016-02-29
Species: All species
Last Modified: 2016-02-29
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.