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The growth factor independence-1 (Gfi1) is overexpressed in chronic myelogenous leukemia.

Authors: Huang, M  Hu, Z  Chang, W  Ou, D  Zhou, J  Zhang, Y 
Citation: Huang M, etal., Acta Haematol. 2010;123(1):1-5. doi: 10.1159/000253856. Epub 2009 Nov 2.
Pubmed: (View Article at PubMed) PMID:19887785
DOI: Full-text: DOI:10.1159/000253856

The activation of ABL tyrosine kinase in BCR/ABL-positive chronic myelogenous leukemia (CML) leads to a diversity of biological changes related to the pathogenesis of the disease. In CML patients, we determined the expression of growth factor independence-1 (Gfi1), a transcription repressor with weak oncogenic activity. Our data demonstrated that the Gfi1 mRNA level in both the mononuclear cells and purified CD34(+) cells from CML were significantly higher as measured by quantitative real-time PCR. Using flow cytometry and Western blot, we also showed that the Gfi1 protein content was increased in CML CD34(+) cells. The expression of Gfi1 was correlated with BCR/ABL significantly. Gfi1 may be implicated in the pathogenesis of CML and can serve as a potential target for the management of the disease.


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CRRD Object Information
CRRD ID: 11040457
Created: 2016-03-08
Species: All species
Last Modified: 2016-03-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.