[The diagnostic of defects of inborn immunity under B-cell tumors of lymphatic system].

Authors: Nazarova, EL  Shardakov, VI  Dem'ianova, VT  Zagoskina, TP  Zotina, EN 
Citation: Nazarova EL, etal., Klin Lab Diagn. 2014 Nov;59(11):39-42.
Pubmed: (View Article at PubMed) PMID:25850245

The genetic characteristics are key risk factors of development of many human neoplasms including B-cell tumors of lymphatic system. The relationship between polymorphic variants of genes FCGR2A (His 1 66Agr), CD14 (C-159T). IL1beta (T-31C), IL2 (7:330G) and 7LR2 (Arg753Ghn) and development of various forms of B-cell tumors of lymphatic system in 80 patients was investigated. The statistically significant differences of rates of particiular genotypes of single nucleotid polymorphisms of genes FCGR2A, CD14. IL1beta, IL2 and TLR2 in patients with indolent and aggressive types of course of non-Hodgkin lymphoma and also multiple myeloma. The results prove hypothesis that genetic variants of genes of inborn immune response effect the origin and character of course of different types of lymphoproliferative diseases. The markers can become additional prognostic characteristics of benign and aggressive course of tumors.

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CRRD ID: 11040778
Created: 2016-03-15
Species: All species
Last Modified: 2016-03-15
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.