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Effects of electroacupuncture on the expression of p70 ribosomal protein S6 kinase and ribosomal protein S6 in the hippocampus of rats with vascular dementia.

Authors: Zhu, Y  Wang, X  Ye, X  Gao, C  Wang, W 
Citation: Zhu Y, etal., Neural Regen Res. 2012 Jan 25;7(3):207-11. doi: 10.3969/j.issn.1673-5374.2012.03.009.
Pubmed: (View Article at PubMed) PMID:25767501
DOI: Full-text: DOI:10.3969/j.issn.1673-5374.2012.03.009

This study investigated the mechanism underlying electroacupuncture therapy for vascular dementia through electroacupuncture at the acupoints of Baihui (DU20), Dazhui (DU14), and bilateral Shenshu (BL23) in a rat model of vascular dementia produced by bilateral middle cerebral artery occlusion. Morris water maze test showed that electroacupuncture improved the learning ability of vascular dementia rats. Western blot assay revealed that the expression of p70 ribosomal protein S6 kinase and ribosomal protein S6 in vascular dementia rats was significantly increased after electroacupuncture, compared with the model group that was not treated with acupuncture. The average escape latency was also shortened after electroacupuncture, and escape strategies in the spatial probe test improved from edge and random searches, to linear and trending swim pathways. The experimental findings indicate that electroacupuncture improves learning and memory ability by up-regulating expression of p70 ribosomal protein S6 kinase and ribosomal protein S6 in the hippocampus of vascular dementia rats.

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CRRD Object Information
CRRD ID: 11041644
Created: 2016-03-25
Species: All species
Last Modified: 2016-03-25
Status: ACTIVE



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