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HLA class II haplotypes distinctly associated with vaso-occlusion in children with sickle cell disease.

Authors: Mahdi, N  Al-Ola, K  Al-Subaie, AM  Ali, ME  Al-Irhayim, Z  Al-Irhayim, AQ  Almawi, WY 
Citation: Mahdi N, etal., Clin Vaccine Immunol. 2008 Apr;15(4):729-31. doi: 10.1128/CVI.00425-07. Epub 2008 Feb 13.
Pubmed: (View Article at PubMed) PMID:18272668
DOI: Full-text: DOI:10.1128/CVI.00425-07

We investigated the association of HLA class II alleles and haplotypes with sickle cell anemia vaso-occlusive crisis (VOC). DRB1*100101 was positively associated, while DRB1*140101, DRB1*150101, and DQB1*060101 were negatively associated, with VOC. Both susceptible (DRB1*100101-DQB1*050101) and protective (DRB1*110101-DQB1*030101 and DRB1*150101-DQB1*060101) haplotypes were identified, indicating that HLA class II haplotypes influence VOC risk.

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CRRD Object Information
CRRD ID: 11041760
Created: 2016-03-28
Species: All species
Last Modified: 2016-03-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.