CD95 (FAS/APO-1) antigen is a new prognostic marker of blast cells of acute lymphoblastic leukaemia patients.

Authors: Baryshnikov, AYU  Polosukhina, ER  Tupitsin, NN  Gavrikova, NV  Andreeva, LYU  Zabotina, TN  Mayakova, SA  Kurmashov, VI  Syrkin, AB  Kadagidze, ZG  Blochin, DYU  Shishkin, YUV 
Citation: Baryshnikov AYu, etal., Adv Exp Med Biol. 1999;457:251-8.
Pubmed: (View Article at PubMed) PMID:10500800

We analyzed CD95(Fas/APO-1) antigen expression on bone marrow blasts in 38 children with acute lymphoblastic leukemia (ALL) receiving a treatment in the Department of Leukaemias at the Cancer Research Center in 1987-1989 years (n = 22) and in 1994-1997 years (n = 16). CD95 antigen expression was studied by monoclonal antibodies (MoAbs) IPO-4 in indirect immunofluorescence analysis. CD95 antigen was expressed on 35.8 +/- 7.5% bone marrow blasts, most frequently (63.6%) in the clinically favourable Pre-B ALL. Only in this group CD95 antigen expression was correlated with CD10 antigen expression that has a positive influence to the time of complete remission in ALL patients. Our data showed that CD95 expression on blast cells is a favourable prognostic sign, associated with increased relapse-free and total survival. On the contrary, the absence of CD95 antigen on blasts is an unfavourable sign for disease evolution.

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CRRD ID: 11049148
Created: 2016-04-05
Species: All species
Last Modified: 2016-04-05
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.