Upregulation of MicroRNA-126 Contributes to Endothelial Progenitor Cell Function in Deep Vein Thrombosis via Its Target PIK3R2.

Authors: Meng, Q  Wang, W  Yu, X  Li, W  Kong, L  Qian, A  Li, C  Li, X 
Citation: Meng Q, etal., J Cell Biochem. 2015 Aug;116(8):1613-23. doi: 10.1002/jcb.25115.
Pubmed: (View Article at PubMed) PMID:25652288
DOI: Full-text: DOI:10.1002/jcb.25115

Deep vein thrombosis (DVT) is a common complication of surgery. Endothelial progenitor cells (EPCs) are recruited into resolving venous thrombi. In this report, we investigated the effects of miR-126 on EPCs function and venous thrombus resolution. We demonstrated that overexpression of miR-126 enhanced EPCs' migration and tubulogenic activity in vitro, and promoted EPCs' homing and thrombus resolving in vivo. Moreover, we identified that miR-126 directly targeted PIK3R2 and affected PI3K/Akt signaling axis. Overall, our findings demonstrated that miR-126 promoted EPCs function through suppressing PIK3R2 expression and modulation of miR-126 may represent a potential therapeutic intervention for treating DVT.


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CRRD Object Information
CRRD ID: 11053232
Created: 2016-04-13
Species: All species
Last Modified: 2016-04-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.