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Analysis of behaviors of plasma tissue factor and tissue factor pathway inhibitor in patients with various diseases

Authors: Saito, M  Morishita, E  Asakura, H  Jokaji, H  Uotani, C  Kumabashiri, I  Yamazaki, M  Aoshima, K  Matsuda, T 
Citation: Saito M, etal., Rinsho Ketsueki. 1996 Sep;37(9):794-8.
Pubmed: (View Article at PubMed) PMID:8914465

We measured plasma levels of tissue factor (TF), total tissue factor pathway inhibitor (TFPI) and free TFPI antigen in patients with diabetes mellitus (DM), hyperlipidemia and disseminated intravascular coagulation (DIC). The mean TF, total TFPI and free TFPI antigen concentrations were significantly higher in patients with DM than in controls and the plasma TF concentration was significantly higher in patients with retinopathy or nephropathy than in DM with no complications. The mean TF, total TFPI and free TFPI antigen concentrations were significantly higher in patients with hyperlipidemia than in controls. There was a significant positive correlation between levels of total TFPI and total cholesterol. In patients with hyperlipidemia, the level of total TFPI was significantly decreased compared to base line level by cholesterol lowering drug, however, free TFPI concentration did not change by cholesterol lowering drug. The TF and total TFPI concentrations were significantly higher in patients with DIC than in controls.

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CRRD Object Information
CRRD ID: 11060253
Created: 2016-04-20
Species: All species
Last Modified: 2016-04-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.