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miR-107 promotes hepatocellular carcinoma cell proliferation by targeting Axin2.

Authors: Zhang, JJ  Wang, CY  Hua, L  Yao, KH  Chen, JT  Hu, JH 
Citation: Zhang JJ, etal., Int J Clin Exp Pathol. 2015 May 1;8(5):5168-74. eCollection 2015.
Pubmed: (View Article at PubMed) PMID:26191213

BACKGROUND: A large number of studies demonstrated that microRNAs play important roles in the progression and development of human cancers. However, the expression level of miR-107 and its biological function in hepatocellular carcinoma (HCC) remains unclear. METHOD: Quantitative real-time PCR (qRT-PCR) was used to evaluate the expression level of miR-107 in HCC tissues and cell lines. Then, we explored the function of miR-107 to determine its potential roles on HCC cell proliferation in vitro. Luciferase reporter assay was used to confirm the target gene of miR-107, and the results were validated in cell lines. RESULTS: miR-107 was significantly up-regulated in HCC tissues and cell lines. The enforced expression of miR-107 was able to promote cell proliferation in HepG2 cells. At the molecular level, our results suggested that expression of Axin2 was negatively regulated by miR-107. CONCLUSION: Our observations suggested that miR-107 could promote HCC cells proliferation via targeting Axin2 and might represent a potential therapeutic target for HCC.

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CRRD Object Information
CRRD ID: 11066920
Created: 2016-04-27
Species: All species
Last Modified: 2016-04-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.