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Lack of association between MDM2 SNP309 and TP53 Arg72Pro polymorphisms with clinical outcomes in myelodysplastic syndrome.

Authors: Machado-Neto, JA  Traina, F  De Melo Campos, P  Andreoli-Risso, MF  Costa, FF  Olalla Saad, ST 
Citation: Machado-Neto JA, etal., Neoplasma. 2012;59(5):530-5. doi: 10.4149/neo_2012_068.
Pubmed: (View Article at PubMed) PMID:22668018
DOI: Full-text: DOI:10.4149/neo_2012_068

MDM2/p53 pathway plays an important role in the control of apoptotic and proliferation mechanisms, and alterations in this pathway have been described in myelodysplastic syndromes (MDS). We investigated the frequency of MDM2 SNP309, TP53 Arg72Pro polymorphisms in de novo MDS and the association of these polymorphisms with clinical characteristics. Our results showed that the frequencies of genotypes for MDM2 SNP309 and TP53 Arg72Pro did not differ between MDS and healthy controls and that these polymorphisms were not associated with clinical and laboratory parameters, disease progression and overall survival, suggesting that MDM2 and TP53 polymorphisms are not involved in risk for MDS, or in the clinical and laboratory characteristics of the disease.


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CRRD Object Information
CRRD ID: 11073731
Created: 2016-05-04
Species: All species
Last Modified: 2016-05-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.