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Mucosal cytokine profiles in paediatric eosinophilic oesophagitis: a case-control study.

Authors: Romano, C  Chiaro, A  Lucarelli, S  Santarelli, C  Cucchiara, S  Guadagnini, T  Miele, E  Di Nardo, G 
Citation: Romano C, etal., Dig Liver Dis. 2014 Jul;46(7):590-5. doi: 10.1016/j.dld.2014.03.003. Epub 2014 Apr 3.
Pubmed: (View Article at PubMed) PMID:24704289
DOI: Full-text: DOI:10.1016/j.dld.2014.03.003

BACKGROUND: Eosinophilic oesophagitis is an inflammatory condition characterized by a dense eosinophilic infiltrate. The migration of eosinophils into the oesophagus is influenced by cytokines such as IL-5, IL-13 and eotaxin-3. The aim of this study was to evaluate changes in the cytokine expression profiles (IL-5, IL-13 and eotaxin-3/CCL26) in children after topical steroid treatment. METHODS: a prospective case-control study was performed in 23 paediatric patients (age 5-16 years) with a histological diagnosis of eosinophilic oesophagitis. Histological evaluation and cytokine levels assay (IL-5, IL-13 and eotaxin-3/CCL26) in the proximal and distal oesophagus were performed before, and after 8 weeks of topical budesonide. Data were compared with a matched healthy control group. RESULTS: quantitative expression levels of IL-5, IL-13 and eotaxin-3 were significantly higher in the eosinophilic oesophagitis group both compared to healthy subjects (p<0.0001). A significant reduction of the eosinophil infiltrate as well as of IL-5, IL-13 and eotaxin-3 mucosal profiles was observed after steroid treatment both at the proximal and distal oesophagus (p<0.0001). CONCLUSIONS: IL-5, IL-13 and eotaxin-3/CCL26 are significantly over-expressed in the oesophageal epithelium of children with eosinophilic oesophagitis. Topical steroid treatment (inhaled and swallowed budesonide) can induce clinical response with partial mucosal remission.


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CRRD Object Information
CRRD ID: 11081157
Created: 2016-05-26
Species: All species
Last Modified: 2016-05-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.