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Genetic variations in benzene metabolism and susceptibility to multiple myeloma.

Authors: Lincz, LF  Scorgie, FE  Robertson, R  Enno, A 
Citation: Lincz LF, etal., Leuk Res. 2007 Jun;31(6):759-63. Epub 2006 Sep 1.
Pubmed: (View Article at PubMed) PMID:16949155
DOI: Full-text: DOI:10.1016/j.leukres.2006.07.012

We have previously shown that deficiency in the biotransformation enzyme glutathione-S-transferase theta (GSTT1) is a risk factor for multiple myeloma (MM). The present case-control study of 102 MM patients and 205 controls revealed a significant trend in increasing risk of MM with inheritance of multiple putative 'high risk' genetic variants in related pathways of benzene detoxification. Individuals who carried polymorphisms for GSTT1 null and/or high activity microsomal epoxide hydrolase (mEH 113YY+139HR or 113YY+139RR or 113YH+139RR) and/or low activity NAD(P)H:quinone oxidoreductase 1 (NQO1 187PS/SS) were 1.65, 2.49 and 13 times more likely to have MM (P(trend)=0.001).


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CRRD Object Information
CRRD ID: 11252121
Created: 2016-06-24
Species: All species
Last Modified: 2016-06-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.