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Polymorphism of XRCC1, XRCC3, and XPD genes and risk of chronic myeloid leukemia.

Authors: Banescu, C  Trifa, AP  Demian, S  Benedek Lazar, E  Dima, D  Duicu, C  Dobreanu, M 
Citation: Banescu C, etal., Biomed Res Int. 2014;2014:213790. doi: 10.1155/2014/213790. Epub 2014 May 15.
Pubmed: (View Article at PubMed) PMID:24955348
DOI: Full-text: DOI:10.1155/2014/213790

The genetic polymorphisms of X-ray repair cross complementing group 1 (XRCC1), X-ray repair cross complementing group 3 (XRCC3), and xeroderma pigmentosum complementation group D (XPD) repair genes may lead to genetic instability and leukemogenesis. The purpose of the study was to evaluate the association between XRCC1 Arg399Gln, Arg280His and Arg194Trp, XRCC3 Thr241Met, and XPD Lys751Gln polymorphisms and the risk of developing CML in Romanian patients. A total of 156 patients diagnosed with CML and 180 healthy controls were included in this study. We found no association between CML and XRCC1 or XRCC3 variant genotypes in any of the investigated cases. A significant difference was observed in the variant genotype frequencies of the XPD Lys751Gln polymorphism between the patients with CML and control group (for variant homozygous genotypes, OR = 2.37; 95% CI = 1.20-4.67; P value = 0.016 and for combined heterozygous and variant homozygous genotypes, OR = 1.72; 95% CI = 1.10-2.69; P value = 0.019). This was also observed when analyzing the variant 751Gln allele (OR = 1.54; 95% CI = 1.13-2.11; P value = 0.008). Our results suggest that the XPD Lys751Gln variant genotype increases the risk of CML.


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CRRD Object Information
CRRD ID: 11252188
Created: 2016-06-28
Species: All species
Last Modified: 2016-06-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.