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The effects of tacrolimus on the activity and expression of tissue factor in the rat ovary with ischemia-reperfusion induced injury.

Authors: Ustundag, UV  Sahin, S  Ak, K  Keskin, I  Emekli-Alturfan, E 
Citation: Ustundag UV, etal., Reprod Biol. 2015 Sep;15(3):139-45. doi: 10.1016/j.repbio.2015.07.002. Epub 2015 Jul 26.
Pubmed: (View Article at PubMed) PMID:26370456
DOI: Full-text: DOI:10.1016/j.repbio.2015.07.002

In the present study, the effects of tacrolimus on the activity and expression of tissue factor (TF) were investigated in the ovarian ischemia-reperfusion induced injury in rats. Twenty-eight female rats (8-12 weeks, 300-350 g) were divided into four groups: control, ischemia-reperfusion (IR), tacrolimus treated before ischemia (TBI), and tacrolimus treated before reperfusion (TBR) groups (n=7/per group). TF activity was measured using Quick's method, whereas TF expression was examined immunohistochemically. TF activity was significantly higher in all treated groups compared with the control group. Strong ovarian TF expression was demonstrated in the IR and TBR groups. Moreover, tacrolimus decreased TF activity in the TBI group compared with the IR group. The decreased activity of TF in the ovarian IR model may prevent IR-related inflammation during transplant procedure.


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CRRD Object Information
CRRD ID: 11341710
Created: 2016-06-30
Species: All species
Last Modified: 2016-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.