Cytotoxic T-lymphocyte antigen-4 microsatellite polymorphism is associated with multiple myeloma.

Authors: Zheng, C  Huang, D  Liu, L  Bjorkholm, M  Holm, G  Yi, Q  Sundblad, A 
Citation: Zheng C, etal., Br J Haematol. 2001 Jan;112(1):216-8.
Pubmed: (View Article at PubMed) PMID:11167807

Multiple myeloma (MM) is a B-lineage malignancy with unknown aetiology. It has been considered that predisposing genetic factors might be implicated in the disease. In this study, the microsatellite polymorphism in the exon 3 of the cytotoxic T-lymphocyte antigen-4 (CTLA-4) gene was analysed in patients with MM and monoclonal gammopathy of undetermined significance (MGUS), together with ethnically matched healthy controls. The results showed that frequencies of the genotype 86/86 and of the allele 86 were significantly decreased in MM and MGUS compared with matched healthy controls, indicating that the CTLA-4 microsatellite polymorphism might represent a susceptibility locus for MM and MGUS.

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CRRD ID: 11352247
Created: 2016-07-12
Species: All species
Last Modified: 2016-07-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.