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Carbon monoxide inhalation: effect on heart cytochrome c in the neonatal and adult rat.

Authors: Penney, DG  Zak, R  Aschenbrenner, V 
Citation: Penney DG, etal., J Toxicol Environ Health. 1983 Aug-Sep;12(2-3):395-406.
Pubmed: (View Article at PubMed) PMID:6317876
DOI: Full-text: DOI:10.1080/15287398309530436

Male rats, 5 and 90 d of age, continuously inhaled 500 ppm CO [40% carboxyhemoglobin (COHb)] for 5.5-8.0 wk. Cardiomegaly and polycythemia developed as previously reported. Heart weight gain in young and old rats treated with CO was accompanied by increased cytochrome c content (nmol) in both left ventricle (LV) and right ventricle (RV) relative to controls. Cytochrome c concentration (nmol/g wet weight), however, was significantly depressed in LV and RV of young CO-exposed rats relative to controls, while there was no change in LV and RV of the old CO-exposed group. LV cytochrome c concentration was significantly higher than that of RV in both young and old, CO-exposed and control rats. On the other hand, cytochrome c concentration in young and old control LVs was similar, as was cytochrome c concentration in RVs of young and old control rats. Three additional experiments were carried out with 5-d-old rats inhaling 500 ppm CO, for 47 and 25 d. These also showed the increase in myocardial cytochrome c content and compromise of cytochrome c concentration, and both changes were greater with longer exposure.

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CRRD Object Information
CRRD ID: 11352705
Created: 2016-07-15
Species: All species
Last Modified: 2016-07-15
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.