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Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk.

Authors: Chubb, D  Weinhold, N  Broderick, P  Chen, B  Johnson, DC  Forsti, A  Vijayakrishnan, J  Migliorini, G  Dobbins, SE  Holroyd, A  Hose, D  Walker, BA  Davies, FE  Gregory, WA  Jackson, GH  Irving, JA  Pratt, G  Fegan, C  Fenton, JA  Neben, K  Hoffmann, P  Nothen, MM  Muhleisen, TW  Eisele, L  Ross, FM  Straka, C  Einsele, H  Langer, C  Dorner, E  Allan, JM  Jauch, A  Morgan, GJ  Hemminki, K  Houlston, RS  Goldschmidt, H 
Citation: Chubb D, etal., Nat Genet. 2013 Oct;45(10):1221-5. doi: 10.1038/ng.2733. Epub 2013 Aug 18.
Pubmed: (View Article at PubMed) PMID:23955597
DOI: Full-text: DOI:10.1038/ng.2733

To identify variants for multiple myeloma risk, we conducted a genome-wide association study with validation in additional series totaling 4,692 individuals with multiple myeloma (cases) and 10,990 controls. We identified four risk loci at 3q26.2 (rs10936599, P = 8.70 x 10(-14)), 6p21.33 (rs2285803, PSORS1C2, P = 9.67 x 10(-11)), 17p11.2 (rs4273077, TNFRSF13B, P = 7.67 x 10(-9)) and 22q13.1 (rs877529, CBX7, P = 7.63 x 10(-16)). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy, as well as insight into the biological basis of predisposition.

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CRRD Object Information
CRRD ID: 11352716
Created: 2016-07-15
Species: All species
Last Modified: 2016-07-15
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.