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Chemokine MCP1/CCL2 gene polymorphism influences Henoch-Schonlein purpura susceptibility in Iranian Azeri-Turkish patients.

Authors: Bonyadi, M  Mohammadian, T  Rafeey, M  Sadeghi Shabestri, M  Mortazavi, F  Aliyari, B 
Citation: Bonyadi M, etal., Int J Dermatol. 2015 Nov;54(11):1269-74. doi: 10.1111/ijd.12940. Epub 2015 Jul 30.
Pubmed: (View Article at PubMed) PMID:26234573
DOI: Full-text: DOI:10.1111/ijd.12940

BACKGROUND: Henoch-Schonlein purpura (HSP) is the most common small-vessel vasculitis and mainly affects children. Although its pathophysiology is unknown, several studies have indicated the possible involvement of infections and genetic factors in the development of HSP. The human leukocyte antigen (HLA) gene family and several other genes involved in the inflammatory system have been studied. The CCL2 gene, encoding chemokine monocyte chemo-attractant protein 1 (MCP-1/CCL2), is one of several cytokine genes clustered on chromosome 17. The encoded protein displays chemotactic activity for monocytes. METHODS: This is a case-control study comparing 36 children diagnosed with HSP within the Iranian Azeri-Turkish ethnic population and 50 healthy adults from the same ethnic group. CCL2, C-2518T polymorphism genotypes were determined by polymerase chain reaction and by PVUII restriction enzyme analysis and subsequent agarose gel electrophoresis. RESULTS: Our results showed a significant association between the allelic and genotypic frequency of this gene and HSP disease in this cohort. The results of this study indicate that frequencies of the T allele of CCL2 (P = 0.015) and the TT genotype (P = 0.004) are significantly higher in HSP patients. A comparison of clinical symptoms and laboratory data with CCL2 C-2518T polymorphism showed that patients with the TT genotype presented a higher clinical score and more severe clinical features. CONCLUSIONS: MCP1/CCL2 C-2518T gene polymorphism is associated with susceptibility to HSP. This is the first study to report a significant association between MCP1/CCL2 C-2518T and a susceptibility to HSP in this population.

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CRRD Object Information
CRRD ID: 11522500
Created: 2016-08-03
Species: All species
Last Modified: 2016-08-03
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.