Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

[Expression of Bcl-2 mRNA and Bcl-2 protein in nasal mucusa of rat in allergic rhinitis model].

Authors: Suo, L  Zhao, C  An, Y  Zhang, X  Tao, Z 
Citation: Suo L, etal., Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2004 Feb;18(2):105-7.
Pubmed: (View Article at PubMed) PMID:15362690

OBJECTIVE: To study the expression of Bcl-2 (B-cell lymphoma/leukemia-2) mRNA and Bcl-2 protein in nasal mucusa of rat in allergic rhinitis (AR) model. METHOD: Twenty male or female SD rats, weighing 180-220 g, free of nasal diseases, were randomly divided into two groups. AR model was established through intraperitoneal injection of ovabumin (OVA) as well as nasal challenge with OVA. The nasal mucusa thus obtained from two groups were studied by HE, in situ hybridization histochemical staining of Bcl-2 mRNA and immunohistochemical staining of bcl-2/bax protein. RESULT: The positive expression of Bcl-2 mRNA and Bcl-2/bax protein was presented in the glandular cells,epithelium cells and eosinophils. The staining density of Bcl-2 mRNA and Bcl-2 protein in AR rats increased significantly as compared with those in normal controls. No significant differences of Bax protein expression in two groups were found. CONCLUSION: Bcl-2 mRNA and Bcl-2 protein were up-regulated in the mucusa of AR rats.


Disease Annotations
Objects Annotated

Additional Information

CRRD Object Information
CRRD ID: 11522724
Created: 2016-08-04
Species: All species
Last Modified: 2016-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.