Association of T-786C eNOS gene polymorphism with increased susceptibility to acute chest syndrome in females with sickle cell disease.

Authors: Sharan, K  Surrey, S  Ballas, S  Borowski, M  Devoto, M  Wang, KF  Sandler, E  Keller, M 
Citation: Sharan K, etal., Br J Haematol. 2004 Jan;124(2):240-3.
Pubmed: (View Article at PubMed) PMID:14687036

Acute chest syndrome (ACS) is a life-threatening complication of sickle cell disease (SCD). A retrospective study was performed to evaluate the role of endothelial nitric oxide synthase (eNOS) gene polymorphisms (E298D and T-786C) in African-American SCD patients. The D298 allele showed no association; the C-786 allele showed a statistically significant association (P = 0.0061) in female ACS cases. Multiple logistic regression analysis showed that relative risk of ACS was 8.695 (P = 0.0076, 95% confidence interval 1.761-42.920) for female carriers of C-786. eNOS T-786C is a gender-specific genetic modifier that is associated with increased susceptibility to ACS in female SCD patients.


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CRRD Object Information
CRRD ID: 11533934
Created: 2016-09-13
Species: All species
Last Modified: 2016-09-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.