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mTOR signaling in growth control and disease.

Authors: Laplante, M  Sabatini, DM 
Citation: Laplante M and Sabatini DM, Cell. 2012 Apr 13;149(2):274-93. doi: 10.1016/j.cell.2012.03.017.
Pubmed: (View Article at PubMed) PMID:22500797
DOI: Full-text: DOI:10.1016/j.cell.2012.03.017

The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis. The pathway regulates many major cellular processes and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration. Here, we review recent advances in our understanding of the mTOR pathway and its role in health, disease, and aging. We further discuss pharmacological approaches to treat human pathologies linked to mTOR deregulation.

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CRRD Object Information
CRRD ID: 11535033
Created: 2016-09-19
Species: All species
Last Modified: 2016-09-19
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.