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Regulation of mTORC1 by amino acids.

Authors: Bar-Peled, L  Sabatini, DM 
Citation: Bar-Peled L and Sabatini DM, Trends Cell Biol. 2014 Jul;24(7):400-6. doi: 10.1016/j.tcb.2014.03.003. Epub 2014 Mar 31.
Pubmed: (View Article at PubMed) PMID:24698685
DOI: Full-text: DOI:10.1016/j.tcb.2014.03.003

The mechanistic target of rapamycin complex I (mTORC1) is a central regulator of cellular and organismal growth, and hyperactivation of this pathway is implicated in the pathogenesis of many human diseases including cancer and diabetes. mTORC1 promotes growth in response to the availability of nutrients, such as amino acids, which drive mTORC1 to the lysosomal surface, its site of activation. How amino acid levels are communicated to mTORC1 is only recently coming to light by the discovery of a lysosome-based signaling system composed of Rags (Ras-related GTPases) and Ragulator v-ATPase, GATOR (GAP activity towards Rags), and folliculin (FLCN) complexes. Increased understanding of this pathway will not only provide insight into growth control but also into the human pathologies triggered by its deregulation.

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Molecular Pathway Annotations
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CRRD Object Information
CRRD ID: 11535043
Created: 2016-09-20
Species: All species
Last Modified: 2016-09-20
Status: ACTIVE



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