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Role of endogenous platelet-derived growth factor in arterial smooth muscle cell migration after balloon catheter injury.

Authors: Jackson, CL  Raines, EW  Ross, R  Reidy, MA 
Citation: Jackson CL, etal., Arterioscler Thromb. 1993 Aug;13(8):1218-26.
Pubmed: (View Article at PubMed) PMID:8343497

The process of intimal thickening after de-endothelializing injury to the rat carotid artery is dependent on the migration of smooth muscle cells from the media. Recent reports have suggested that platelet-derived growth factor may be an important mediator of migration after injury. We have addressed this issue by directly determining smooth muscle cell migration in injured arteries of animals depleted of platelets and after administration of an antibody that blocks platelet-derived growth factor. Because there is a reported association between plasminogen activator synthesis and smooth muscle cell migration, we assayed the activity levels of plasminogen activators after arterial injury and also assessed the effect of a plasmin inhibitor on migration. The data suggest that platelet-derived growth factor, released by platelets at sites of arterial injury, is an endogenous mediator of smooth muscle cell migration; that plasmin generation, catalyzed by tissue-type plasminogen activator, is necessary for migration; and that one way in which platelet-derived growth factor may act is by stimulation of the synthesis of tissue-type plasminogen activator by smooth muscle cells.


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CRRD Object Information
CRRD ID: 11537479
Created: 2016-10-05
Species: All species
Last Modified: 2016-10-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.