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Microcephaly disease gene Wdr62 regulates mitotic progression of embryonic neural stem cells and brain size.

Authors: Chen, JF  Zhang, Y  Wilde, J  Hansen, KC  Lai, F  Niswander, L 
Citation: Chen JF, etal., Nat Commun. 2014 May 30;5:3885. doi: 10.1038/ncomms4885.
Pubmed: (View Article at PubMed) PMID:24875059
DOI: Full-text: DOI:10.1038/ncomms4885

Human genetic studies have established a link between a class of centrosome proteins and microcephaly. Current studies of microcephaly focus on defective centrosome/spindle orientation. Mutations in WDR62 are associated with microcephaly and other cortical abnormalities in humans. Here we create a mouse model of Wdr62 deficiency and find that the mice exhibit reduced brain size due to decreased neural progenitor cells (NPCs). Wdr62 depleted cells show spindle instability, spindle assembly checkpoint (SAC) activation, mitotic arrest and cell death. Mechanistically, Wdr62 associates and genetically interacts with Aurora A to regulate spindle formation, mitotic progression and brain size. Our results suggest that Wdr62 interacts with Aurora A to control mitotic progression, and loss of these interactions leads to mitotic delay and cell death of NPCs, which could be a potential cause of human microcephaly.

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CRRD Object Information
CRRD ID: 11541053
Created: 2016-10-06
Species: All species
Last Modified: 2016-10-06
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.