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20 alpha-hydroxysteroid dehydrogenase expression in a murine virus-induced myeloproliferative syndrome.

Authors: Marcovistz, R  Le Bousse-Kerdiles, MC  Maillere, B  Smadja-Joffe, F  Poirrier, V  Jasmin, C 
Citation: Marcovistz R, etal., Biochimie. 1991 Nov;73(11):1351-3.
Pubmed: (View Article at PubMed) PMID:1665987

The myeloproliferative sarcoma virus (MPSV) infection in DBA/2 mice leads to important quantitative and qualitative changes in their hemopoiesis. These findings suggest a disturbance in the production and action of a certain hemopoietic factor similar to IL3. Here, we show that the level of the 20 alpha-hydroxysteroid dehydrogenase (20 alpha-SDH) expression, which can be induced by IL3, is dramatically increased in spleen and thymus of MPSV-infected mice. Our results suggest that quantification of 20 alpha-SDH activity can be used to indicate abnormal production of a growth factor similar to IL3 in hemopoietic system diseases.

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CRRD Object Information
CRRD ID: 11552589
Created: 2016-10-11
Species: All species
Last Modified: 2016-10-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.