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Nasal and pharyngeal eosinophil peroxidase levels in adults with poorly controlled asthma correlate with sputum eosinophilia.

Authors: Rank, M A  Ochkur, S I  Lewis, J C  Teaford, H G  Wesselius, L J  Helmers, R A  Lee, N A  Nair, P  Lee, J J 
Citation: Rank MA, etal., Allergy. 2016 Apr;71(4):567-70. doi: 10.1111/all.12817. Epub 2015 Dec 24.
Pubmed: (View Article at PubMed) PMID:26645423
DOI: Full-text: DOI:10.1111/all.12817

The objective of the study was to compare nasal, pharyngeal, and sputum eosinophil peroxidase (EPX) levels with induced sputum eosinophil percentage in 10 adults with poorly controlled asthma and 10 normal controls. EPX was measured using an ELISA and normalized for grams of protein for nasal and pharynx specimens and for mL-gram of protein for sputum. Sputum EPX levels were statistically different between asthma and control subjects (P = 0.024). EPX levels measured in the nasal and pharyngeal swab samples derived from the same patients were also different between asthma and control subjects, each displaying a high degree of significance (P = 0.002). Spearman's correlation coefficients for nasal EPX and pharyngeal EPX levels compared to induced sputum eosinophil percentage were 0.81 (P = 0.0007) and 0.78 (P = 0.0017), respectively. Thus, there is a strong association in a given patient between both nasal and pharyngeal EPX levels and the eosinophil percentage of induced sputum.


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CRRD Object Information
CRRD ID: 11574908
Created: 2016-12-22
Species: All species
Last Modified: 2016-12-22
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.