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Elevated serum insulin-like growth factor (IGF-1) and IGF binding protein-3 levels in patients with systemic sclerosis: possible role in development of fibrosis.

Authors: Hamaguchi, Yasuhito  Fujimoto, Manabu  Matsushita, Takashi  Hasegawa, Minoru  Takehara, Kazuhiko  Sato, Shinichi 
Citation: Hamaguchi Y, etal., J Rheumatol. 2008 Dec;35(12):2363-71. doi: 10.3899/jrheum.080340. Epub 2008 Nov 1.
Pubmed: (View Article at PubMed) PMID:19004037
DOI: Full-text: DOI:10.3899/jrheum.080340


OBJECTIVE: To examine serum concentrations of insulin-like growth factor (IGF-1) and IGF binding protein (IGFBP-3), a major carrier protein for IGF-1, in patients with systemic sclerosis (SSc); and to relate the results to clinical features in SSc.
METHODS: Serum IGF-1 and IGFBP-3 levels in 92 Japanese patients with SSc were measured by ELISA. Expression of IGF-1 and IGFBP-3 messenger RNA (mRNA) in the skin was quantified by real-time reverse transcription-polymerase chain reaction.
RESULTS: Serum IGF-1 and IGFBP-3 levels were significantly elevated in patients with SSc compared with patients with systemic lupus erythematosus or healthy controls. IGF-1 levels were higher in patients with diffuse cutaneous SSc (dcSSc) than in patients with limited cutaneous SSc (lcSSc). Patients with increased IGF-1 levels had more severe skin involvement and pulmonary fibrosis. IGF-1 mRNA was upregulated in the affected skin of patients with SSc. There were no significant differences in serum IGFBP-3 levels between dcSSc and lcSSc. IGFBP-3 levels were not associated with skin thickness and pulmonary fibrosis. Patients with increased IGF-1 or IGFBP-3 had lower frequency of telangiectasia than patients with normal levels.
CONCLUSION: These results suggest that both IGF-1 and IGFBP-3 are involved in the development of SSc. The role of IGF-1 appears to be different from that of IGFBP-3.

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CRRD Object Information
CRRD ID: 12743606
Created: 2017-02-09
Species: All species
Last Modified: 2017-02-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.