Proteomic detection of cancer in asbestosis patients using SELDI-TOF discovered serum protein biomarkers.

Authors: Tooker, Brian C  Newman, Lee S  Bowler, Russell P  Karjalainen, Antti  Oksa, Panu  Vainio, Harri  Pukkala, Eero  Brandt-Rauf, Paul W 
Citation: Tooker BC, etal., Biomarkers. 2011 Mar;16(2):181-91. doi: 10.3109/1354750X.2010.543289. Epub 2011 Jan 14.
Pubmed: (View Article at PubMed) PMID:21231887
DOI: Full-text: DOI:10.3109/1354750X.2010.543289


OBJECTIVES: To identify biomarkers for cancer in asbestosis patients.
METHODS: SELDI-TOF and CART were used to identify serum biomarker profiles in 35 asbestosis patients who subsequently developed cancer and 35 did not develop cancer.
RESULTS: Three polypeptide peaks (5707.01, 6598.10, and 20,780.70 Da) could predict the development of cancer with 87% sensitivity and 70% specificity. The first two peaks were identified as KIF18A and KIF5A, respectively, and are part of the Kinesin Superfamily of proteins.
CONCLUSIONS: We identified two Kinesin proteins that can be potentially used as blood biomarkers to identify asbestosis patients at risk of developing lung cancer.

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CRRD Object Information
CRRD ID: 12793066
Created: 2017-03-20
Species: All species
Last Modified: 2017-03-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.