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Basal cell carcinomas in mice overexpressing sonic hedgehog.

Authors: Oro, A E  Higgins, K M  Hu, Z  Bonifas, J M  Epstein, E H  Scott, M P 
Citation: Oro AE, etal., Science. 1997 May 2;276(5313):817-21.
Pubmed: (View Article at PubMed) PMID:9115210

Mutations in the tumor suppressor gene PATCHED (PTC) are found in human patients with the basal cell nevus syndrome, a disease causing developmental defects and tumors, including basal cell carcinomas. Gene regulatory relationships defined in the fruit fly Drosophila suggest that overproduction of Sonic hedgehog (SHH), the ligand for PTC, will mimic loss of ptc function. It is shown here that transgenic mice overexpressing SHH in the skin develop many features of basal cell nevus syndrome, demonstrating that SHH is sufficient to induce basal cell carcinomas in mice. These data suggest that SHH may have a role in human tumorigenesis.


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CRRD Object Information
CRRD ID: 12802345
Created: 2017-04-05
Species: All species
Last Modified: 2017-04-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.