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miR-761 regulates the mitochondrial network by targeting mitochondrial fission factor.

Authors: Long, Bo  Wang, Kun  Li, Na  Murtaza, Iram  Xiao, Jing-Ying  Fan, Yuan-Yuan  Liu, Cui-Yun  Li, Wen-Hui  Cheng, Zheng  Li, Peifeng 
Citation: Long B, etal., Free Radic Biol Med. 2013 Dec;65:371-9. doi: 10.1016/j.freeradbiomed.2013.07.009. Epub 2013 Jul 15.
Pubmed: (View Article at PubMed) PMID:23867156
DOI: Full-text: DOI:10.1016/j.freeradbiomed.2013.07.009

Mitochondria are dynamic organelles that constantly undergo fission and fusion. The balance between fission and fusion determines the fate of the cell. In this study, we show that mitochondrial fission factor (MFF) is upregulated upon hydrogen peroxide treatment or ischemia/reperfusion (I/R) injury. Knockdown of MFF attenuated hydrogen peroxide- and I/R injury-induced cardiomyocyte apoptosis and myocardial infarction. We found that MFF is a direct target of miR-761, and miR-761 inhibits mitochondrial fission and cardiomyocyte apoptosis by repressing MFF. This study reveals a novel model of mitochondrial fission regulation, which is composed of miR-761 and MFF. Modulation of their levels may provide a new approach for tackling apoptosis and myocardial infarction.


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CRRD Object Information
CRRD ID: 12879458
Created: 2017-04-20
Species: All species
Last Modified: 2017-04-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.