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[The expression and role of glucose transporter-1 in infantile hemangioma].

Authors: Yuan, Si-Ming  Jiang, Hui-Qing  Hong, Zhi-Jian  Wang, Jun  Hu, Xin-Bao  Ouyang, Tian-Xiang  Xing, Xin 
Citation: Yuan SM, etal., Zhonghua Zheng Xing Wai Ke Za Zhi. 2007 Mar;23(2):90-3.
Pubmed: (View Article at PubMed) PMID:17554865

OBJECTIVE: To investigate the expression and role of glucose transporter-1 (Glut1) in infantile hemangioma.
METHODS: Fifty-two samples from infantile hemangioma, 25 in cavernous venous malformation, 9 in arteriovenous malformation, 2 in capillary malformation and 5 in normal skin samples were involved in this study. The EnVision immunohistochemical stain was used to investigate the expression of Glut1 protein in these samples.
RESULTS: In the early proliferating stage, a number of endothelial cells expressed Glut1. In the middle proliferating stage, most of vascular endothelial cells and scattered endothelial cells expressed Glut1. In the late proliferating stage, the expression of Glut1 decreased quickly. In the involuting stage, all hemangioma samples didn't express Glut1. All of the samples from the cavernous venous malformations, arteriovenous malformations, capillary malformations and normal skin had no expression of Glut1.
CONCLUSIONS: Glut1 may be one of the phenotypes of infantile hemangioma endothelial cells in their development, rather than the inherent character. The expression of Glut1 changes according to the metabolic need of infantile hemangioma cells.


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CRRD Object Information
CRRD ID: 12879502
Created: 2017-04-24
Species: All species
Last Modified: 2017-04-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.