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Tumor necrosis factor-alpha allele lymphotoxin-alpha+250 is associated with the presence and severity of placental inflammation among preterm births.

Authors: Kazzi, S Nadya J  Jacques, Suzanne M  Qureshi, Faisal  Quasney, Michael W  Kim, U Olivia  Buhimschi, Irina A 
Citation: Kazzi SN, etal., Pediatr Res. 2004 Jul;56(1):94-8. Epub 2004 May 5.
Pubmed: (View Article at PubMed) PMID:15128916
DOI: Full-text: DOI:10.1203/01.PDR.0000130474.12948.A4

Histologic inflammation of placenta has been associated with increased risk for bronchopulmonary dysplasia and periventricular leukomalacia among preterm infants. Tumor necrosis factor-alpha (TNF-alpha) plays a central role in the regulation of inflammation. Some alleles of TNF (LT-alpha+250, TNF-alpha-308, and TNF-alpha-238) have been associated with susceptibility and/or severity of many diseases characterized by inflammation and/or involving the immune system. To determine whether alleles of TNF-alpha affect the risk and/or the severity of chorioamnionitis, we examined the placentas of 101 preterm births (birth weight


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CRRD Object Information
CRRD ID: 12904055
Created: 2017-05-16
Species: All species
Last Modified: 2017-05-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.