Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

Delta-aminolevulinate dehydratase activity in mice with hereditary anemia.

Authors: Margolis, F L  Russell, E S 
Citation: Margolis FL and Russell ES, Science. 1965 Oct 22;150(3695):496-7.
Pubmed: (View Article at PubMed) PMID:5891055

Homozygous (f/f) but not heterozygous (f/+) mice of the highly congenic strain, FL/ Re, manifest a severe transitory siderocytic fetal anemia. Adults of both f/f and f/+ genotype manifest decreased hepatic, splenic, and renal levels of triangle up-amino-levulinate dehydratase (ALD) activity compared to homozygous (+/+) mice of the same strain. The degree of augmentation in splenic ALD activity following phenylhydrazine administration is high in +/+, intermediate in f/+, and low in f/f mice. These findings suggest that perhaps a deficiency in the fetal level of ALD may be responsible for the transitory fetal anemia.


Disease Annotations
Objects Annotated

Additional Information

CRRD Object Information
CRRD ID: 12904678
Created: 2017-05-17
Species: All species
Last Modified: 2017-05-17
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.