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Nonsyndromic mental retardation and cryptogenic epilepsy in women with doublecortin gene mutations.

Authors: Guerrini, Renzo  Moro, Francesca  Andermann, Eva  Hughes, Elaine  D'Agostino, Daniela  Carrozzo, Romeo  Bernasconi, Andrea  Flinter, Frances  Parmeggiani, Lucio  Volzone, Anna  Parrini, Elena  Mei, Davide  Jarosz, Jozef M  Morris, Robin G  Pratt, Polly  Tortorella, Gaetano  Dubeau, Fran├žois  Andermann, Frederick  Dobyns, William B  Das, Soma 
Citation: Guerrini R, etal., Ann Neurol. 2003 Jul;54(1):30-7.
Pubmed: (View Article at PubMed) PMID:12838518
DOI: Full-text: DOI:10.1002/ana.10588

DCX mutations cause mental retardation in male subjects with lissencephalypachygyria and in female subjects with subcortical band heterotopia (SBH). We observed four families in which carrier women had normal brain magnetic resonance imaging (MRI) and mild mental retardation, with or without epilepsy. Affected male subjects had SBH or pachygyria-SBH. In two families, the phenotype was mild in both genders. In the first family, we found a tyr138his mutation that is predicted to result in abnormal folding in the small hinge region. In the second family, we found an arg178cys mutation at the initial portion of R2, in the putative beta-sheet structure. Carrier female subjects with normal MRI showed no somatic mosaicism or altered X-inactivation in lymphocytes, suggesting a correlation between mild mutations and phenotypes. In the two other families, with severely affected boys, we found arg76ser and arg56gly mutations within the R1 region that are predicted to affect DCX folding, severely modifying its activity. Both carrier mothers showed skewed X-inactivation, possibly explaining their mild phenotypes. Missense DCX mutations may manifest as non-syndromic mental retardation with cryptogenic epilepsy in female subjects and SBH in boys. Mutation analysis in mothers of affected children is mandatory, even when brain MRI is normal.


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CRRD Object Information
CRRD ID: 12904728
Created: 2017-05-19
Species: All species
Last Modified: 2017-05-19
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.