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[Neurogenesis in the dentate gyrus of the hippocampus in a rat model of intracerebral hemorrhage].

Authors: Xu, Xi  Zheng, Jianyun  Zhang, Junfeng  Chne, Xinlin  Yang, PengBo  Liu, Jianxin  Liu, Yong 
Citation: Xu X, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2013 Oct;33(10):1437-41.
Pubmed: (View Article at PubMed) PMID:24144742


OBJECTIVE: To investigate whether intracerebral hemorrhage (ICH) can promote neurogenesis in the dentate gyrus (DG) of rat hippocampus.
METHODS: Western blot analysis, immunohistochemical staining, and immunofluorescent double labeling combined with confocal microscope were used to detect neurogenesis in the DG of the hippocampus in rats after ICH.
RESULTS: The expression of DCX protein in the ipsilateral DG of the hippocampus was enhanced in the rats 1 day after ICH (0.202±0.062) as compared with that in normal rats (0.127±0.088), reaching the peak level at 14 days (0.771±0.108, P<0.01) and beginning to decrease at 28 days (0.582±0.121, P<0.01). Meanwhile, DCX-positive cells and BrdU-positive cells, and DCX/BrdU double-labeled cells were detected in the DG of the hippocampus. Compared with those in the control group, BrdU/NeuN double-labeled cells were markedly increased in the granular cell layer of the DG at 28 days after ICH (1.808±1.020 vs 5.654±1.671, P<0.01).
CONCLUSION: ICH can promote neurogenesis in the DG of rat hippocampus.

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CRRD Object Information
CRRD ID: 12904766
Created: 2017-05-23
Species: All species
Last Modified: 2017-05-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.