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Insulin-like growth factor-I down-regulates ghrelin receptor (growth hormone secretagogue receptor) expression in the rat pituitary.

Authors: Kamegai, Jun  Tamura, Hideki  Shimizu, Takako  Ishii, Shinya  Sugihara, Hitoshi  Oikawa, Shinichi 
Citation: Kamegai J, etal., Regul Pept. 2005 Apr 15;127(1-3):203-6.
Pubmed: (View Article at PubMed) PMID:15680488
DOI: Full-text: DOI:10.1016/j.regpep.2004.12.001

The effects of insulin-like growth factor-I (IGF-I) on the ghrelin receptor [growth hormone secretagogue receptor (GHS-R)] gene expression and on the GH response to GHS in rat pituitary cell cultures were examined. Pituitary GHS-R mRNA levels were decreased in a dose (0.01-10 nM)- and time (4-12 h)-dependent manner by IGF-I as measured with reverse transcriptase (RT)-PCR. The basal GH secretion was not influenced by the pretreatment with IGF-I (1 nM for 8 h); however, the GH response to the receptor ligand, a synthetic GHS, KP-102 (100 nM, 15 min), was significantly reduced by pretreatment with IGF-I. Thus, the present studies indicate that IGF-I could inhibit GH secretion at least in part by regulating the expression of the GHS-R.


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CRRD Object Information
CRRD ID: 12907504
Created: 2017-06-06
Species: All species
Last Modified: 2017-06-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.