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A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting.

Authors: Brauer, AU  Savaskan, NE  Kuhn, H  Prehn, S  Ninnemann, O  Nitsch, R 
Citation: Brauer AU, etal., Nat Neurosci 2003 Jun;6(6):572-8.
Pubmed: (View Article at PubMed) PMID:12730698
DOI: Full-text: DOI:10.1038/nn1052

Outgrowth of axons in the central nervous system is governed by specific molecular cues. Molecules detected so far act as ligands that bind to specific receptors. Here, we report a new membrane-associated lipid phosphate phosphatase that we have named plasticity-related gene 1 (PRG-1), which facilitates axonal outgrowth during development and regenerative sprouting. PRG-1 is specifically expressed in neurons and is located in the membranes of outgrowing axons. There, it acts as an ecto-enzyme and attenuates phospholipid-induced axon collapse in neurons and facilitates outgrowth in the hippocampus. Thus, we propose a novel mechanism by which axons are able to control phospholipid-mediated signaling and overcome the growth-inhibiting, phospholipid-rich environment of the extracellular space.


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CRRD Object Information
CRRD ID: 1299556
Created: 2004-06-01
Species: All species
Last Modified: 2006-04-25
Status: ACTIVE


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