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Rat model of familial combined hyperlipidemia as a result of comparative mapping.

Authors: Ueno, T  Tremblay, J  Kunes, J  Zicha, J  Dobesova, Z  Pausova, Z  Deng, AY  Sun, YL  Jacob, HJ  Hamet, P 
Citation: Ueno T, etal., Physiol Genomics 2004 Mar 12;17(1):38-47. Epub 2004 Jan 6.
Pubmed: (View Article at PubMed) PMID:14709677
DOI: Full-text: DOI:10.1152/physiolgenomics.00043.2003

Total genome scan was carried out in 266 F2 intercrosses from the Prague hypertriglyceridemic (HTG) rat that shares several clinical characteristics with human metabolic syndrome. Two loci for plasma triglycerides (TG) were localized on chromosome 2 (Chr 2) (LOD 4.4, 3.2). The first locus overlapped with the rat syntenic region of the human locus for the metabolic syndrome and for small, dense LDL, while the second overlapped with the syntenic region of another locus for small, dense LDL in humans by the comparative mapping approach. Loci for TG on rat Chr 13 (LOD 3.3) and Chr 1 (LOD 2.7) overlapped with the syntenic region of loci for human familial combined hyperlipidemia (FCHL) in Finnish and Dutch populations, respectively. The concordances of loci for TG localized in this study with previously reported loci for FCHL and its related phenotypes are underlying the generalized importance of these loci in dyslipidemia. These data suggest the close relationship between dyslipidemia in HTG rats and human FCHL, establishing a novel animal model for exploration of pathophysiology and therapy based on genomic determinants.


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CRRD Object Information
CRRD ID: 1299960
Created: 2004-06-23
Species: All species
Last Modified: 2004-06-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.