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A rat mutation producing demyelination (dmy) maps to chromosome 17.

Authors: Kuramoto, T  Sotelo, C  Yokoi, N  Serikawa, T  Gonalons Sintes, E  Canto Martorell, J  Guenet, JL 
Citation: Kuramoto T, etal., Mamm Genome 1996 Dec;7(12):890-4.
Pubmed: (View Article at PubMed) PMID:8995759

A recessive mutation exhibiting severe myelin breakdown, mainly at the level of the lumbar segments of the spinal cord and without any associated inflammation, was discovered in a partially inbred rat colony. Analysis of the segregation patterns of a set of polymorphic microsatellite markers in two inter-strain crosses allowed the mapping of this autosomal recessive mutation to rat Chromosome (Chr) 17, very close to the prolactin (Prl) locus, in a region homologous to human Chr 6p21.2-22.3 and mouse Chr 13. The pathology of the demyelination process and the chromosomal localization indicate that this mutation has no known equivalent in either mouse or human.


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Additional Information

CRRD Object Information
CRRD ID: 1300413
Created: 2004-07-25
Species: All species
Last Modified: 2004-07-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.